Photo: AP

A Puerto Rican man in his 70s who died from complications of the Zika virus was the first case of his kind in the U.S., The New York Times first reported on Friday.

The man’s case was one of 683 confirmed Zika infections in Puerto Rico, according to the Centers for Disease Control. The outbreak includes 89 pregnant women.

Deaths are not particularly common when it comes to Zika—the main worry about the virus is its potential link to birth fetal malformations and neurological disorders in newborns. Transmitted primarily by Aedes mosquitoes, there is no vaccine for Zika; the best form of prevention is avoiding mosquito bites.

In U.S. states excluding Puerto Rico, there have been 426 travel-related cases of Zika reported. With the coming of climate change, that number could go up.