Beau Biden, the son of Vice President Joe Biden and a former Attorney General of Delaware, has died of brain cancer. He was 46.

The Vice President’s office confirmed the death in a statement:

It is with broken hearts that Hallie, Hunter, Ashley, Jill and I announce the passing of our husband, brother and son, Beau, after he battled brain cancer with the same integrity, courage and strength he demonstrated every day of his life.

The entire Biden family is saddened beyond words. We know that Beau’s spirit will live on in all of us—especially through his brave wife, Hallie, and two remarkable children, Natalie and Hunter.

Earlier this week, Biden was hospitalized at Walter Reed Medical Center. He suffered a minor stroke in 2010 and underwent surgery in 2013 to remove a brain lesion. In 1972, Beau and his younger brother, Hunter, survived a car crash that killed his mother and 13-month-old sister.

Biden served two terms as Attorney General for Delaware and had announced plans to run for governor in 2016. He’s survived by his wife, Hallie, and two children.

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